李聚学，教授，理学博士，博士生（硕士生）导师
科学研究方向
下丘脑调控能量代谢和下丘脑调控精子发生
联系方式
通讯：江苏省南京市江宁区龙眠大道101号学海楼，邮编211166
电邮：lijuxue@njmu.edu.cn
简介
李聚学，男，教授，南京医科大学基础医学院生物化学与分子生物学系教授，博士生导师。国家级重大人才工程A类青年项目入选者，2020 年江苏省双创人才”。2008年毕业于中国科学院动物研究所，获博士学位。先后在美国威斯康辛大学，美国阿尔伯特爱因斯坦医学院和新西兰皇家农业研究所从事代谢和胚胎发育相关的研究工作。共发表SCI论文 21 篇。部分论文发表在Nature、Nature Cell Biology 、ACS Nano、PNAS、和Cell Research等著名期刊上，受到了国内外广泛的关注和积极的评价。目前，发表的论文被引用1500多次。回国后的研究方向主要集中在下丘脑调控能量代谢和下丘脑调控精子发生等领域。主要涉及包括下丘脑代谢相关神经元以及神经干细胞在代谢调控、生殖调控及其机制研究，已构建多款基因敲除小鼠，拟通过生物信息学和基因敲除等技术研究下丘脑调控能量代谢/下丘脑调控精子发生的分子机理。
近年来主持和参与的科研项目
1. 2021年江苏省“双创团队”项目，项目骨干，在研，150万，2021.09-2024.09；
2. 国自然面上项目，主持，在研，55万，2021.01-2024.12；
3. 国家重大研究计划培育项目，主持，在研，60万，2021.01-2023.12；
4. 2020年江苏省“双创人才”项目，主持，在研，50万，2020.09-2023.09；
5. 国家重点研发计划子课题，主持，已结题，783万，2018.12-2021.12；
6. 国家级重大人才工程A类青年项目，主持，200万，2017.12-2020.12；
7. 国自然面上项目，主持，已结题，58万，2016.01-2019.12
代表性论文
1. Pang J#, Feng X#, Liang Q#, Zheng X#, Duan Y#, Zhang X, Zhang J, Chen Y, Fan K*, Gao L*, Li J*. Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model. ACS Nano. 2022 Mar 22;16(3):4175-4185.
2. Zheng X#, Duan Y#, Pang J#, Feng X#, Gao L*, Li J*. Antibacterial effects of nano-decoction iron polysulfide in epididymitis and the systematic evaluation of its toxicity on the reproductive health of male mice. Ecotoxicol Environ Saf. 2022 Feb;231:113184.
3. Zhang Y, Guan Y, Pan S, Yan L, Wang P, Chen Z, Shen Q, Zhao F, Zhang X, Li J, Li J*, Cai D*, Zhang G*. Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20149-20158.
4. Li J, Tang Y, Purkayastha S, Yan J, Cai D. Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus. Mol Metab. 2014;3(3):313-24.
5. Zhang G#, Li J#, Purkayastha S#, Tang Y#, Zhang H#, Yin Y, et al. Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH. Nature. 2013; 497(7448):211-6. （共同第一作者论文）
6. Li J, Tang Y, Cai D. IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol. 2012; 14(10):999-1012. （第一作者论文）
7. Li J, Miao C, Guo W, Jia L, Zhou J, Ma B, et al. Enrichment of putative human epidermal stem cells based on cell size and collagen type IV adhesiveness. Cell Res.2008;18(3):360-71.（第一作者论文）
合作作者论文
1. Zhao W, Jin Y, Wu P, Yang J, Chen Y, Yang Q, Huo X, Li J, De W, Chen J, Yang F. LINC00355 induces gastric cancer proliferation and invasion through promoting ubiquitination of P53. Cell Death Discov. 2020 Oct 8;6:99.
2. Shen Q, Chen Z, Zhao F, Pan S, Zhang T, Cheng X, Zhang L, Zhang S, Qi J, Li J, Cai D, Zhang G. Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1. Nat Neurosci. 2020 Jul;23(7):832-841.
3. Liu J, Liu Y, Peng L, Li J, Wu K, Xia L, Wu J, Wang S, Wang X, Liu Q, Zeng W, Xia Y. TWEAK/Fn14 Signals Mediate Burn Wound Repair. J Invest Dermatol. 2019 Jan;139(1):224-234.
4. Wang HH, Zhou CL, Lv M, Yang Q, Li JX, Hou M, Lin J, Liu XM, Wu YT, Sheng JZ, Huang HF. Prenatal High Estradiol Exposure Induces Sex-Specific and Dietarily Reversible Insulin Resistance Through Decreased Hypothalamic INSR. Endocrinology. 2018 Jan 1;159(1):465-476.
5. Yan X, Zhao X, Li J, He L, Xu M. Effects of early-life malnutrition on neurodevelopment and neuropsychiatric disorders and the potential mechanisms. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Apr 20;83:64-75.
6. Tian S, Lin XH, Xiong YM, Liu ME, Yu TT, Lv M, Zhao W, Xu GF, Ding GL, Xu CM, Jin M, Feng C, Wu YT, Tan YJ, Gao Q, Zhang J, Li C, Ren J, Jin LY, Chen B, Zhu H, Zhang XY, Chen SC, Liu XM, Liu Y, Zhang JY, Wang L, Zhang P, Chen XJ, Jin L, Chen X, Meng YC, Wu DD, Lin H, Yang Q, Zhou CL, Li XZ, Wang YY, Xiang YQ, Liu ZW, Gao L, Chen LT, Pan HJ, Li R, Zhang FH, Xing LF, Zhu YM, Klausen C, Leung PCK, Li JX, Sun F, Sheng JZ, Huang HF. Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism. EBioMedicine. 2017 Feb;16:275-283.
7. Yan J, Zhang H, Yin Y, Li J, Tang Y, Purkayastha S, et al. Obesity- and aging-induced excess of central transforming growth factor-beta potentiates diabetic development via an RNA stress response. Nat Med. 2014; 20(9):1001-8.
8. Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, et al. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 2011;69(3):523-35.
9. Qiu Z, Miao C, Li J, Lei X, Liu S, Guo W, et al. Skeletal myogenic potential of mouse skin-derived precursors. Stem Cells Dev. 2010;19(2):259-68.
10. Guo W, Miao C, Liu S, Qiu Z, Li J, Duan E. Efficient differentiation of insulin-producing cells from skin-derived stem cells. Cell Prolif. 2009;42(1):49-62.
11. Peng S, Li J, Miao C, Jia L, Hu Z, Zhao P, et al. Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation. Reproduction. 2008;135(3):367-75.
12. Jia L, Zhou J, Peng S, Li J, Cao Y, Duan E. Effects of Wnt3a on proliferation and differentiation of human epidermal stem cells. Biochem Biophys Res Commun. 2008;368(3):483-8.
13. Wei Q, Zheng X,Li J (7th).The study of gene transfer and heredity in Mouse.Laboratory Animal Science and Management.2005; 23(1), 3-6.
14. Zhao Y,Zheng X, Cao B, Wei Q, Li L, Wei Y ,Li J. Establishment of a new method for early embryo culture in vitro.Hereditas.2004; 26(3), 364－366.
