报告题目：Smart Drug Delivery Triggered by Physiological Signals
报告人：顾臻教授，美国北卡大学教堂山分校澳门威斯人0168、医学院
报告时间：2014年7月8日上午10:00
报告地点：江宁校区药学楼310室
主办单位：澳门威斯人0168 临床药学系
报告地点：江宁校区药学楼310室
主办单位：澳门威斯人0168 临床药学系
报告摘要：Spurred by recent advanced in molecular pharmaceutics and materials chemistry, stimuli-responsive “smart” systems offer opportunities for delivering drugs in dose-, spatial- and temporal-controlled fashions. In this talk, I will discuss our ongoing efforts in using physiological signals, such as blood sugar level, enzyme activity and ATP gradient for on-demand drug release. I will first present the glucose-responsive closed-loop systems for biomimetic delivery of insulin. Next, I will discuss enzyme-activated formulations for delivery of cytokine, apoptotic executor and transcription factors in a programmed manner. Finally, I will introduce our recent work on ATP-mediated anticancer drug delivery.
三篇代表作：
1) Mo R, Jiang T, DiSanto R, Tai W, Gu Z. ATP-triggered anticancer drug delivery. Nat Commun; 5:3364.
2) Mo R, Jiang T, Di J, Tai W, Gu Z. Emerging micro- and nanotechnology based synthetic approaches for insulin delivery. Chem Soc Rev; 43:3595-629.
3) Yu JC, Chen YL, Zhang YQ, Yao XK, Qian CG, Huang J, et al. pH-Responsive and near-infrared-emissive polymer nanoparticles for simultaneous delivery, release, and fluorescence tracking of doxorubicin in vivo. Chem Commun (Camb); 50:4699-702.
